Analysis of long non-coding RNA RMRP in the diagnosis and prognosis of coronary artery disease.
J Cardiothorac Surg
; 19(1): 341, 2024 Jun 21.
Article
in En
| MEDLINE
| ID: mdl-38907341
ABSTRACT
BACKGROUND:
Long non-coding RNAs (lncRNAs) are abundant and closely related to the occurrence and development of human diseases. LncRNAs are known to play a key role in many cardiovascular diseases. The purpose of this study was to investigate the effect of the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP) on the degree of coronary artery lesions and prognosis in patients with coronary artery disease (CAD).METHODS:
Patients who underwent coronary angiography (CAG) and dynamical-single photon emission computed tomography (D-SPECT) were selected as study subjects, and the results of CAG were reviewed, and the patients were grouped according to SYNTAX score. Evaluate the factors affecting SYNTAX scores. The follow-up analysis was conducted, and the endpoint events were major adverse cardiovascular events (MACEs). Kaplan-Meier method was used to estimate the survival rate, and multivariate Cox regression was used to analyze the relationship between RMRP and MACEs.RESULTS:
The expression level of serum RMRP in patients with CAD was significantly higher than that in healthy people. Multivariate Logistic regression analysis showed that age, low-density lipoprotein cholesterol (LDL-C), RMRP and rest left ventricular ejection fraction (LVEF) were independent factors that affected SYNTAX scores. There were 19 cases of MACEs in the high RMRP group and 9 cases in the low RMRP group, and there was a significant difference in the MACE free survival curve between the two groups. Multivariate Cox regression analysis showed that age, SYNTAX score, rest LVEF and RMRP were risk factors for MACEs.CONCLUSIONS:
Serum RMRP is a key factor affecting the degree of coronary artery disease and prognosis in CAD patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronary Artery Disease
/
Coronary Angiography
/
RNA, Long Noncoding
Limits:
Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
J Cardiothorac Surg
/
J. cardiothorac. surg. (Online)
/
Journal of cardiothoracic surgery (Online)
Year:
2024
Document type:
Article