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The Advancing Role of Nanocomposites in Cancer Diagnosis and Treatment.
Andoh, Vivian; Ocansey, Dickson Kofi Wiredu; Naveed, Hassan; Wang, Naijian; Chen, Liang; Chen, Keping; Mao, Fei.
Affiliation
  • Andoh V; School of Life Sciences, Jiangsu University, Zhenjiang, People's Republic of China.
  • Ocansey DKW; Department of Laboratory Medicine, Lianyungang Clinical College, Jiangsu University, Lianyungang, Jiangsu, People's Republic of China.
  • Naveed H; Directorate of University Health Services, University of Cape Coast, Cape Coast, Central Region, CC0959347, Ghana.
  • Wang N; School of Life Sciences, Jiangsu University, Zhenjiang, People's Republic of China.
  • Chen L; Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.
  • Chen K; School of Life Sciences, Jiangsu University, Zhenjiang, People's Republic of China.
  • Mao F; School of Life Sciences, Jiangsu University, Zhenjiang, People's Republic of China.
Int J Nanomedicine ; 19: 6099-6126, 2024.
Article in En | MEDLINE | ID: mdl-38911500
ABSTRACT
The relentless pursuit of effective cancer diagnosis and treatment strategies has led to the rapidly expanding field of nanotechnology, with a specific focus on nanocomposites. Nanocomposites, a combination of nanomaterials with diverse properties, have emerged as versatile tools in oncology, offering multifunctional platforms for targeted delivery, imaging, and therapeutic interventions. Nanocomposites exhibit great potential for early detection and accurate imaging in cancer diagnosis. Integrating various imaging modalities, such as magnetic resonance imaging (MRI), computed tomography (CT), and fluorescence imaging, into nanocomposites enables the development of contrast agents with enhanced sensitivity and specificity. Moreover, functionalizing nanocomposites with targeting ligands ensures selective accumulation in tumor tissues, facilitating precise imaging and diagnostic accuracy. On the therapeutic front, nanocomposites have revolutionized cancer treatment by overcoming traditional challenges associated with drug delivery. The controlled release of therapeutic agents from nanocomposite carriers enhances drug bioavailability, reduces systemic toxicity, and improves overall treatment efficacy. Additionally, the integration of stimuli-responsive components within nanocomposites enables site-specific drug release triggered by the unique microenvironment of the tumor. Despite the remarkable progress in the field, challenges such as biocompatibility, scalability, and long-term safety profiles remain. This article provides a comprehensive overview of recent developments, challenges, and prospects, emphasizing the transformative potential of nanocomposites in revolutionizing the landscape of cancer diagnostics and therapeutics. In Conclusion, integrating nanocomposites in cancer diagnosis and treatment heralds a new era for precision medicine.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nanocomposites / Neoplasms Limits: Animals / Humans Language: En Journal: Int J Nanomedicine Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nanocomposites / Neoplasms Limits: Animals / Humans Language: En Journal: Int J Nanomedicine Year: 2024 Document type: Article