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Long-term prognostic implications of brachial-ankle pulse wave velocity in patients undergoing percutaneous coronary intervention.
Kim, Byung Sik; Ahn, Jong-Hwa; Shin, Jeong-Hun; Kang, Min Gyu; Kim, Kye-Hwan; Bae, Jae Seok; Cho, Yun Ho; Koh, Jin-Sin; Park, Yongwhi; Hwang, Seok-Jae; Tantry, Udaya S; Gurbel, Paul A; Hwang, Jin-Yong; Jeong, Young-Hoon.
Affiliation
  • Kim BS; Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Hanyang University Guri Hospital, Guri-si, Republic of Korea.
  • Ahn JH; Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon-si, Republic of Korea.
  • Shin JH; Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Hanyang University Guri Hospital, Guri-si, Republic of Korea.
  • Kang MG; Department of Internal Medicine, Gyeongsang National University School of Medicine and Division of Cardiology, Gyeongsang National University Hospital, Jinju-si, Republic of Korea.
  • Kim KH; Department of Internal Medicine, Gyeongsang National University School of Medicine and Division of Cardiology, Gyeongsang National University Hospital, Jinju-si, Republic of Korea.
  • Bae JS; Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon-si, Republic of Korea.
  • Cho YH; Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon-si, Republic of Korea.
  • Koh JS; Department of Internal Medicine, Gyeongsang National University School of Medicine and Division of Cardiology, Gyeongsang National University Hospital, Jinju-si, Republic of Korea.
  • Park Y; Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon-si, Republic of Korea.
  • Hwang SJ; Department of Internal Medicine, Gyeongsang National University School of Medicine and Division of Cardiology, Gyeongsang National University Hospital, Jinju-si, Republic of Korea.
  • Tantry US; Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Baltimore, MD, United States.
  • Gurbel PA; Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Baltimore, MD, United States.
  • Hwang JY; Department of Internal Medicine, Gyeongsang National University School of Medicine and Division of Cardiology, Gyeongsang National University Hospital, Jinju-si, Republic of Korea.
  • Jeong YH; CAU Thrombosis and Biomarker Center, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong-si, Republic of Korea.
Front Med (Lausanne) ; 11: 1384981, 2024.
Article in En | MEDLINE | ID: mdl-38912344
ABSTRACT

Objective:

The long-term clinical effect of arterial stiffness in high-risk disease entities remains unclear. The prognostic implications of brachial-ankle pulse wave velocity (baPWV) were assessed using a real-world registry that included patients who underwent percutaneous coronary intervention (PCI).

Methods:

Arterial stiffness was measured using baPWV before discharge. The primary outcome was net adverse clinical events (NACE), defined as a composite of all-cause death, non-fatal myocardial infarction, non-fatal stroke, or major bleeding. Secondary outcomes included major adverse cardiac and cerebrovascular events (MACCE a composite of all-cause death, non-fatal myocardial infarction, or non-fatal stroke), and major bleeding. The outcomes were assessed over a 4-year period.

Results:

Patients (n = 3,930) were stratified into high- and low-baPWV groups based on a baPWV cut-off of 1891 cm/s determined through time-dependent receiver operating characteristic curve analysis. baPWV was linearly correlated with 4-year post-PCI clinical events. The high baPWV group had a greater cumulative incidence of NACE, MACCE, and major bleeding. According to multivariable analysis, the high baPWV groups had a significantly greater risk of 4-year NACE (adjusted hazard ratio [HRadj] 1.44; 95% confidence interval [CI] 1.12-1.85; p = 0.004), MACCE (HRadj 1.40; 95% CI 1.07-1.83; p = 0.015), and major bleeding (HRadj 1.94; 95% CI 1.15-3.25; p = 0.012).

Conclusion:

In PCI-treated patients, baPWV was significantly associated with long-term clinical outcomes, including ischemic and bleeding events, indicating its value for identifying high-risk phenotypes.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Med (Lausanne) Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Med (Lausanne) Year: 2024 Document type: Article