Phylogenetic Survival Analysis.
Methods Mol Biol
; 2833: 121-128, 2024.
Article
in En
| MEDLINE
| ID: mdl-38949706
ABSTRACT
Going back in time through a phylogenetic tree makes it possible to evaluate ancestral genomes and assess their potential to acquire key polymorphisms of interest over evolutionary time. Knowledge of this kind may allow for the emergence of key traits to be predicted and pre-empted from currently circulating strains in the future. Here, we present a novel genome-wide survival analysis and use the emergence of drug resistance in Mycobacterium tuberculosis as an example to demonstrate the potential and utility of the technique.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phylogeny
/
Mycobacterium tuberculosis
Limits:
Humans
Language:
En
Journal:
Methods Mol Biol
Year:
2024
Document type:
Article