Established the prediction model of early-stage non-small cell lung cancer spread through air spaces (STAS) by radiomics and genomics features.
Asia Pac J Clin Oncol
; 2024 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-38952146
ABSTRACT
BACKGROUND:
This study was aimed to establish a prediction model for spread through air spaces (STAS) in early-stage non-small cell lung cancer based on imaging and genomic features.METHODS:
We retrospectively collected 204 patients (47 STAS+ and 157 STAS-) with non-small cell lung cancer who underwent surgical treatment in the Jinling Hospital from January 2021 to December 2021. Their preoperative CT images, genetic testing data (including next-generation sequencing data from other hospitals), and clinical data were collected. Patients were randomly divided into training and testing cohorts (73).RESULTS:
The study included a total of 204 eligible patients. STAS were found in 47 (23.0%) patients, and no STAS were found in 157 (77.0%) patients. The receiver operating characteristic curve showed that radiomics model, clinical genomics model, and mixed model had good predictive performance (area under the curve [AUC] = 0.85; AUC = 0.70; AUC = 0.85).CONCLUSIONS:
The prediction model based on radiomics and genomics features has a good prediction performance for STAS.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Asia Pac J Clin Oncol
/
Asia Pac. j. clin.oncol
/
Asia Pacific journal of clinical oncology
Year:
2024
Document type:
Article