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From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation.
Soni, Dheeraj; Borriello, Francesco; Scott, David A; Feru, Frederic; DeLeon, Maria; Brightman, Spencer E; Cheng, Wing Ki; Melhem, Gandolina; Smith, Jennifer A; Ramirez, Juan C; Barman, Soumik; Cameron, Michael; Kelly, Aisling; Walker, Kristina; Nanishi, Etsuro; van Haren, Simon Daniel; Phan, Tony; Qi, Yizhi; Kinsey, Robert; Raczy, Michal M; Ozonoff, Al; Pettengill, Matthew A; Hubbell, Jeffery A; Fox, Christopher B; Dowling, David J; Levy, Ofer.
Affiliation
  • Soni D; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Borriello F; Harvard Medical School, Boston, MA, USA.
  • Scott DA; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Feru F; Harvard Medical School, Boston, MA, USA.
  • DeLeon M; Harvard Medical School, Boston, MA, USA.
  • Brightman SE; Dana-Farber Cancer Institute, Boston, MA, USA.
  • Cheng WK; Harvard Medical School, Boston, MA, USA.
  • Melhem G; Dana-Farber Cancer Institute, Boston, MA, USA.
  • Smith JA; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Ramirez JC; Harvard Medical School, Boston, MA, USA.
  • Barman S; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Cameron M; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Kelly A; Harvard Medical School, Boston, MA, USA.
  • Walker K; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Nanishi E; Harvard Medical School, Boston, MA, USA.
  • van Haren SD; Harvard Medical School, Boston, MA, USA.
  • Phan T; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Qi Y; Harvard Medical School, Boston, MA, USA.
  • Kinsey R; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Raczy MM; Harvard Medical School, Boston, MA, USA.
  • Ozonoff A; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
  • Pettengill MA; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Hubbell JA; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Fox CB; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
  • Dowling DJ; Harvard Medical School, Boston, MA, USA.
  • Levy O; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Sci Adv ; 10(27): eadg3747, 2024 Jul 05.
Article in En | MEDLINE | ID: mdl-38959314
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Adjuvants, Immunologic / Toll-Like Receptor 7 / Toll-Like Receptor 8 Limits: Animals / Female / Humans Language: En Journal: Sci Adv Year: 2024 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Adjuvants, Immunologic / Toll-Like Receptor 7 / Toll-Like Receptor 8 Limits: Animals / Female / Humans Language: En Journal: Sci Adv Year: 2024 Document type: Article