Factors influencing recovery in a pediatric sample with disorders of consciousness: insights from an observational study.
Brain Inj
; 38(12): 1026-1034, 2024 Oct 14.
Article
in En
| MEDLINE
| ID: mdl-38967329
ABSTRACT
OBJECTIVE:
To estimate rates and time to reach emergence of consciousness from vegetative state/unresponsive wakefulness syndrome (VS/UWS), and explore factors associated with improved recovery in children and adolescents with disorders of consciousness (DoC) following severe traumatic and non-traumatic brain injury.METHODS:
Analytical, retrospective, cohort study. Clinical records of consecutively referred patients admitted in VS/UWS to a neurological rehabilitation institute in Argentina, between 2005 and 2021 were reviewed. Seventy children and adolescents were included in the analysis. A specialized 12-week rehabilitation program was administered, and emergence was defined by scores ≥44 points on the Western Neuro Sensory Stimulation Profile (WNSSP), sustained for at least 3 weeks on consecutive weekly evaluations.RESULTS:
Emergence from VS/UWS to consciousness occurred within 5.4 (SD 2.6) weeks in almost one-third of patients. Multivariate Cox regression analysis showed emergence was significantly lower in patients with hypoxic ischemic encephalopathy compared to patients with other non-traumatic etiologies [HRadj 0.23 (95% CI 0.06-0.89); p = 0.03)].CONCLUSIONS:
Our findings reinforce growing evidence on the impact of etiology on DoC recovery in pediatric populations, ultimately influencing treatment and family-related decisions in child neurorehabilitation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Consciousness Disorders
/
Recovery of Function
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Argentina
Language:
En
Journal:
Brain Inj
Year:
2024
Document type:
Article