Your browser doesn't support javascript.
loading
Research advances in huntingtin-associated protein 1 and its application prospects in diseases.
Wu, Yongjiang; Wang, Yanfei; Lu, Yunchi; Yan, Junguo; Zhao, Hongjun; Yang, Riyun; Pan, Jingying.
Affiliation
  • Wu Y; Department of Histology and Embryology, Medical School of Nantong University, Nantong, China.
  • Wang Y; Department of Histology and Embryology, Medical School of Nantong University, Nantong, China.
  • Lu Y; Department of Histology and Embryology, Medical School of Nantong University, Nantong, China.
  • Yan J; Department of Histology and Embryology, Medical School of Nantong University, Nantong, China.
  • Zhao H; Department of Histology and Embryology, Medical School of Nantong University, Nantong, China.
  • Yang R; Department of Histology and Embryology, Medical School of Nantong University, Nantong, China.
  • Pan J; Department of Histology and Embryology, Medical School of Nantong University, Nantong, China.
Front Neurosci ; 18: 1402996, 2024.
Article in En | MEDLINE | ID: mdl-38975245
ABSTRACT
Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. HAP1 has diverse functions involving in vesicular transport, receptor recycling, gene transcription, and signal transduction. HAP1 is strongly linked to several neurological diseases, including Huntington's disease, Alzheimer's disease, epilepsy, ischemic stroke, and depression. In addition, HAP1 has been proved to participate in cancers and diabetes mellitus. This article provides an overview of HAP1 regarding the tissue distribution, cell localization, functions, and offers fresh perspectives to investigate its role in diseases.
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Neurosci Year: 2024 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Neurosci Year: 2024 Document type: Article