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Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease.
Julovi, Sohel M; Trinh, Katie; Robertson, Harry; Xu, Cuicui; Minhas, Nikita; Viswanathan, Seethalakshmi; Patrick, Ellis; Horowitz, John D; Meijles, Daniel N; Rogers, Natasha M.
Affiliation
  • Julovi SM; Kidney Injury Group, Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
  • Trinh K; Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
  • Robertson H; Kidney Injury Group, Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
  • Xu C; Kidney Injury Group, Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
  • Minhas N; Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
  • Viswanathan S; Sydney Precision Data Science Centre, University of Sydney, New South Wales, Australia.
  • Patrick E; Kidney Injury Group, Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
  • Horowitz JD; Kidney Injury Group, Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
  • Meijles DN; Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
  • Rogers NM; Tissue Pathology and Diagnostic Oncology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia.
JACC Basic Transl Sci ; 9(5): 607-627, 2024 May.
Article in En | MEDLINE | ID: mdl-38984053
ABSTRACT
Patients with chronic kidney disease (CKD) face a high risk of cardiovascular disease. Previous studies reported that endogenous thrombospondin 1 (TSP1) involves right ventricular remodeling and dysfunction. Here we show that a murine model of CKD increased myocardial TSP1 expression and produced left ventricular hypertrophy, fibrosis, and dysfunction. TSP1 knockout mice were protected from these features. In vitro, indoxyl sulfate is driving deleterious changes in cardiomyocyte through the TSP1. In patients with CKD, TSP1 and aryl hydrocarbon receptor were both differentially expressed in the myocardium. Our findings summon large clinical studies to confirm the translational role of TSP1 in patients with CKD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JACC Basic Transl Sci Year: 2024 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JACC Basic Transl Sci Year: 2024 Document type: Article