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Tool to Resolve Distortions in Elemental and Isotopic Imaging.
Lu, Chixiang; Chen, Gu; Song, Wenxin; Chen, Kai; Hee, Charmaine; Nikan, Mehran; Guagliardo, Paul; Bennett, C Frank; Seth, Punit; Iyer, Killugudi Swaminathan; Young, Stephen G; Qi, Xiaojuan; Jiang, Haibo.
Affiliation
  • Lu C; Department of Chemistry, The University of Hong Kong, Pok Fu Lam, Hong Kong 999077, P. R. China.
  • Chen G; Department of Chemistry, The University of Hong Kong, Pok Fu Lam, Hong Kong 999077, P. R. China.
  • Song W; Departments of Medicine, University of California, Los Angeles, California 90095, United States.
  • Chen K; School of Molecular Sciences, University of Western Australia, Perth 6009, Australia.
  • Hee C; School of Molecular Sciences, University of Western Australia, Perth 6009, Australia.
  • Nikan M; Ionis Pharmaceuticals, Inc., Carlsbad, California 92010, United States.
  • Guagliardo P; Centre for Microscopy, Characterisation and Analysis, University of Western Australia, Perth 6009, Australia.
  • Bennett CF; Ionis Pharmaceuticals, Inc., Carlsbad, California 92010, United States.
  • Seth P; Ionis Pharmaceuticals, Inc., Carlsbad, California 92010, United States.
  • Iyer KS; School of Molecular Sciences, University of Western Australia, Perth 6009, Australia.
  • Young SG; Departments of Medicine, University of California, Los Angeles, California 90095, United States.
  • Qi X; Human Genetics, University of California, Los Angeles, California 90095, United States.
  • Jiang H; Electrical and Electronic Engineering, The University of Hong Kong, Pok Fu Lam, Hong Kong 999077, P. R. China.
J Am Chem Soc ; 146(29): 20221-20229, 2024 Jul 24.
Article in En | MEDLINE | ID: mdl-38985464
ABSTRACT
Nanoscale secondary ion mass spectrometry (NanoSIMS) makes it possible to visualize elements and isotopes in a wide range of samples at a high resolution. However, the fidelity and quality of NanoSIMS images often suffer from distortions because of a requirement to acquire and integrate multiple image frames. We developed an optical flow-based algorithm tool, NanoSIMS Stabilizer, for all-channel postacquisition registration of images. The NanoSIMS Stabilizer effectively deals with the distortions and artifacts, resulting in a high-resolution visualization of isotope and element distribution. It is open source with an easy-to-use ImageJ plugin and is accompanied by a Python version with GPU acceleration.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Am Chem Soc Year: 2024 Document type: Article
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PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Am Chem Soc Year: 2024 Document type: Article