Functional imaging in late-onset epilepsy: A focused review.
Seizure
; 2024 Jun 25.
Article
in En
| MEDLINE
| ID: mdl-38991884
ABSTRACT
INTRODUCTION:
About 25 % of new-onset epilepsies are diagnosed after age 65. Late-onset epilepsy (LOE) is predicted to become a major healthcare problem in the next 15 years as the global population increases and ages. Neurodegenerative disorders account for 10-20 % of LOE, while over 20 % of these patients have an unknown etiology. Established diagnostic tools such as FDG-PET and novel biomarkers of neurodegeneration including amyloid and tau PET hold a lot of promise in diagnosing and ruling out neurodegenerative disorders in these patients.METHODS:
We conducted a literature search to identify articles involving LOE populations and using one or more functional neuroimaging techniques.RESULTS:
A total of 5 studies were identified through Boolean searching and snowballing. These were highly heterogenous with respect to operational definitions of LOE, analyses and interpretation pipelines.CONCLUSION:
While there is some evidence for feasibility and usefulness of FDG- and Amyloid PET in LOE, methodological heterogeneities in the available literature preclude any notable conclusions. Future research in this field will benefit from a consensus on epilepsy-specific analysis and interpretation guidelines for amyloid and tau PET.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Seizure
Year:
2024
Document type:
Article