A closed-loop negative feedback model for the pancreas: A new paradigm and pathway to a cure.
Medicine (Baltimore)
; 103(28): e38802, 2024 Jul 12.
Article
in En
| MEDLINE
| ID: mdl-38996137
ABSTRACT
BACKGROUND AND AIMS:
To develop a model that describes how the pancreas functions, how the rate of synthesis of digestive enzymes is regulated, and finally what puts the pancreas to rest between meals.METHODS:
We applied the principals of control theory to previously published canine data to develop a model for how the canine pancreas functions. Using this model, we then describe the steps needed to apply this model to the human pancreas.RESULTS:
This new closed-loop negative feedback model describes what regulates digestive enzyme synthesis. This model is based on basolateral exocytosis of butyrylcholinesterase (BCHE) into the interstitial space. It is this level of BCHE * BCHE activity that controls the rate of canine pancreas digestive enzyme synthesis, and in the absence of stimulation from the vagus nerve, puts the pancreas to rest between meals.CONCLUSIONS:
Finding secretagogue-specific inhibitory enzymes in the human pancreas that are analogous to BCHE in the canine, and blocking its associated receptors, may lead to a cure for human pancreatitis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreas
/
Butyrylcholinesterase
/
Feedback, Physiological
Limits:
Animals
/
Humans
Language:
En
Journal:
Medicine (Baltimore)
Year:
2024
Document type:
Article