Vitamin C inhibits NLRP3 inflammasome activation and delays the development of age-related hearing loss in male C57BL/6 mice.
Neurosci Lett
; 836: 137897, 2024 Jul 27.
Article
in En
| MEDLINE
| ID: mdl-39004114
ABSTRACT
The efficacy of vitamin C in age-related hearing loss, i.e., presbycusis, remains debatable. On a separate note, inflammation induced by the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is involved in the progression of presbycusis. In this study, we investigated the effect of vitamin C on male C57BL/6 mice's presbycusis and NLRP3 inflammasome. The results showed that vitamin C treatment improved hearing, reduced the production of inflammatory factors, inhibited NLRP3 inflammasome activation, and decreased cytosolic mitochondrial DNA (mtDNA) in the C57BL/6 mouse cochlea, inferior colliculus, and auditory cortex. According to this study, vitamin C protects auditory function in male C57BL/6 presbycusis mice through reducing mtDNA release, inhibiting the NLRP3 inflammasome activation in the auditory pathway. Our study provides a theoretical basis for applying vitamin C to treat presbycusis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Presbycusis
/
Ascorbic Acid
/
DNA, Mitochondrial
/
Inflammasomes
/
NLR Family, Pyrin Domain-Containing 3 Protein
/
Mice, Inbred C57BL
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
2024
Document type:
Article