Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model.
Neurosci Bull
; 40(8): 1037-1052, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39014176
ABSTRACT
Posttraumatic stress disorder (PTSD) is a complex mental disorder notable for traumatic experience memory. Although current first-line treatments are linked with clinically important symptom reduction, a large proportion of patients retained to experience considerable residual symptoms, indicating pathogenic mechanism should be illustrated further. Recent studies reported that newly formed myelin could shape neural circuit function and be implicated in fear memory preservation. However, its role in PTSD remains to be elucidated. In this study, we adopted a restraint stress-induced PTSD mouse model and found that PTSD-related neuropsychiatric symptoms were accompanied by increased myelination in the posterior parietal cortex and hippocampus. Fluoxetine, but not risperidone or sertraline, has a more profound rescue effect on neuropsychological behaviors and myelin abnormalities. Further mechanistic experiments revealed that fluoxetine could directly interfere with oligodendroglial differentiation by upregulating Wnt signaling. Our data demonstrated the correlation between PTSD and abnormal myelination, suggesting that the oligodendroglial lineage could be a target for PTSD treatment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stress Disorders, Post-Traumatic
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Fluoxetine
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Disease Models, Animal
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Mice, Inbred C57BL
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Myelin Sheath
Limits:
Animals
Language:
En
Journal:
Neurosci Bull
Year:
2024
Document type:
Article