Periodontitis and Chronic Obstructive Pulmonary Disease: A bidirectional Mendelian randomization study.
Community Dent Health
; 41(3): 177-182, 2024 Aug 30.
Article
in En
| MEDLINE
| ID: mdl-39038197
ABSTRACT
OBJECTIVE:
Observational studies have suggested an association between chronic periodontitis (CP) and chronic obstructive pulmonary disease (COPD). This study aimed to determine whether there is a causal relationship between CP and COPD incidence.DESIGN:
Twosample Mendelian Randomization (MR) analysis using summary statistics from two genomewide association studies (GWASs) of European ancestry. Single nucleotide polymorphisms (SNPs) associated with COPD were obtained from the FinnGen database, which included 16,380,382 SNPs. The diagnosis of COPD was based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD 2023). We also obtained SNPs associated with CP from the FinnGen database, which included 16,380,378 SNPs.RESULTS:
Sixteen eligible SNPs were extracted to analyze the causal effect of CP on COPD incidence. There was no causal correlation between CP and COPD using the inverse variance-weighted method (IVW) (OR=0.97, 95%CI= 0.91-1.05; p=0.482). Seven eligible SNPs were extracted to analyze the causal effect of COPD on CP incidence. Again, there was also no causal correlation between using IVW (OR=1.09, 95%CI=0.93-1.28; p=0.279).CONCLUSION:
We did not demonstrate a causal relationship between genetically predicted CP and COPD, or between genetically predicted COPD and CP.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Single Nucleotide
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Pulmonary Disease, Chronic Obstructive
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Genome-Wide Association Study
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Mendelian Randomization Analysis
Limits:
Humans
Language:
En
Journal:
Community Dent Health
Year:
2024
Document type:
Article