Visible Light-Induced Electron-Donor-Acceptor-Mediated C-3 Coupling of Quinoxalin-2(1H)-ones with Unactivated Aryl Iodides.
Org Lett
; 26(30): 6471-6476, 2024 Aug 02.
Article
in En
| MEDLINE
| ID: mdl-39042831
ABSTRACT
Visible light-induced C-3 arylation of quinoxalin-2(1H)-ones with abundantly available aryl iodides with good yields via an electron-donor-acceptor (EDA)-complex formation have been accomplished. The radical scavenging, Electron paramagnetic resonance (EPR), UV-visible experiments, density functional theory (DFT), and quantum yield studies revealed that the reaction went through a radical pathway via a single electron transfer (SET) process. Furthermore, the protocol could also be applied to the synthesis of biologically active molecules, illustrating the practicality of the present protocol.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Year:
2024
Document type:
Article