Systematic Review of Prevalence of Histoplasma Antigenuria in Persons with HIV in Latin America and Africa.
Emerg Infect Dis
; 30(8): 1523-1530, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39043389
ABSTRACT
Histoplasmosis is a fungal disease associated with substantial mortality rates among persons with advanced HIV disease. Our systematic review synthesized data on the global prevalence of Histoplasma--caused antigenuria in persons with HIV. We searched PubMed/Medline, Embase, and Scopus databases on January 3, 2023, to identify cross-sectional and cohort studies evaluating Histoplasma antigenuria prevalence among adults with HIV infection. We calculated point estimates and 95% CIs to summarize prevalence. Of 1,294 studies screened, we included 15. We found Histoplasma antigenuria among 581/5,096 (11%; 95% CI 11%-12%) persons with HIV and 483/3,789 persons with advanced HIV disease (13%; 95% CI 12%-14%). Among persons with HIV and symptoms consistent with histoplasmosis, Histoplasma antigenuria prevalence was 14% (95% CI 13%-15%; 502/3,631 participants). We determined that persons with advanced HIV disease, inpatients, and symptomatic persons might benefit from a systematic approach to early detection of histoplasmosis using urine antigen testing.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
Histoplasma
/
Histoplasmosis
/
Antigens, Fungal
Limits:
Humans
Country/Region as subject:
Africa
Language:
En
Journal:
Emerg Infect Dis
Year:
2024
Document type:
Article