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Association between Cerebrospinal Fluid sTREM2 Levels and Depression: The Alzheimer's Disease Neuroimaging Initiative Study.
Wang, Y; Ye, M; Ji, Q; Liu, Q; Xu, X; Zhan, Y.
Affiliation
  • Wang Y; Xiaowei Xu, Department of Neurology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China; E-mail: xuxw23@mail.sysu.edu.cn; Yiqiang Zhan, School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen, China; E-mail: zhanyq8@mail.sysu.edu.cn.
J Prev Alzheimers Dis ; 11(4): 1087-1092, 2024.
Article in En | MEDLINE | ID: mdl-39044521
ABSTRACT

OBJECTIVE:

Previous studies demonstrated a significant protective effect of elevated cerebrospinal fluid (CSF) sTREM2 levels on brain structure and cognitive decline. Nonetheless, the role of sTREM2 in the depression progression remains unclear. This study aimed to investigate the association between CSF sTREM2 levels and longitudinal trajectories of depression.

METHODS:

Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) Study were used. CSF sTREM2 levels and depression were measured using an ELISA-based assay and the Geriatric Depression Scale (GDS-15), respectively. Linear mixed-effect models were employed to assess the relationships between CSF sTREM2 levels and GDS scores.

RESULTS:

A total of 1,017 participants were enrolled at baseline, with a mean follow-up time of 4.65 years. Baseline CSF sTREM2 levels were negatively correlated with GDS scores (ß=-0.21, P=0.022) after adjustment for age, gender, race/ethnicity, education, APOE ε4 carrier status, TREM2 rare variant carrier status, marital status, smoking, and clinical cognitive status.

CONCLUSION:

Our findings suggested that a higher level of CSF sTREM2 was associated with a lower risk of depression.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Receptors, Immunologic / Depression / Alzheimer Disease Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: J Prev Alzheimers Dis Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Receptors, Immunologic / Depression / Alzheimer Disease Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: J Prev Alzheimers Dis Year: 2024 Document type: Article