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Longitudinal on-treatment circulating tumor DNA as a biomarker for real-time dynamic risk monitoring in cancer patients: The EP-SEASON study.
Lv, Jiawei; Xu, Ling-Xin; Li, Zhi-Xuan; Lin, Li; Wu, Chen-Fei; Quan, Ting-Qiu; Zhen, Zi-Cheng; Li, Wen-Fei; Tang, Ling-Long; Mao, Yan-Ping; Chen, Lei; Guo, Rui; Zhang, Lu-Lu; Ai, Xin-Lei; Wu, Shi-Yue; Hao, Meng-Yu; Wei, Denghui; Li, Ji-Bin; Ma, Jun; Chen, Yu-Pei; Zhou, Guan-Qun; Sun, Ying.
Affiliation
  • Lv J; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Xu LX; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Li ZX; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Lin L; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Wu CF; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Quan TQ; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Zhen ZC; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Li WF; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Tang LL; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Mao YP; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Chen L; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Guo R; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Zhang LL; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
  • Ai XL; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Wu SY; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Hao MY; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Wei D; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China.
  • Li JB; Clinical Trial Centre, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
  • Ma J; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China. Electronic address:
  • Chen YP; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China. Electronic address:
  • Zhou GQ; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China. Electronic address:
  • Sun Y; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Department of Radiation Oncology, Guangzhou 510060, China. Electronic address:
Cancer Cell ; 42(8): 1401-1414.e4, 2024 Aug 12.
Article in En | MEDLINE | ID: mdl-39059389
ABSTRACT
Recurrence risks of cancer patient can change during treatment as a result of treatment-related tumor evolution. However, biomarkers that can monitor these changes are lacking. Here, we investigated whether tracking circulating tumor DNA (ctDNA) dynamics through liquid biopsy can inform real-time recurrence risk. Nasopharyngeal carcinoma (NPC) provides an ideal model where cell-free Epstein-Barr virus (EBV) DNA (cfEBV DNA), a ctDNA, can be sensitively detected. We conducted the EP-SEASON study (NCT03855020) and prospectively recruited 1,000 NPC patients undergoing per-protocol cfEBV DNA assessments at 11 time points and receiving sequential chemo-radiotherapy. Longitudinal cfEBV DNA displayed distinct patterns during neoadjuvant chemotherapy and radiotherapy. Despite the prognostic significance of cfEBV DNA at each time point, real-time recurrence risks changed in sync with cfEBV DNA dynamics. Furthermore, we identified phenotypes of whole-course ctDNA changing dynamics associated with different survival outcomes. In conclusion, tracking longitudinal on-treatment ctDNA can forecast real-time recurrence risk, facilitating risk-adapted, individualized patient management.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Nasopharyngeal Neoplasms / Circulating Tumor DNA / Nasopharyngeal Carcinoma / Neoplasm Recurrence, Local Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Cancer Cell Year: 2024 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Nasopharyngeal Neoplasms / Circulating Tumor DNA / Nasopharyngeal Carcinoma / Neoplasm Recurrence, Local Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Cancer Cell Year: 2024 Document type: Article