An overview of the development of pharmacotherapeutics targeting SARS-CoV-2.
Drug Discov Today
; 29(9): 104126, 2024 Aug 02.
Article
in En
| MEDLINE
| ID: mdl-39097220
ABSTRACT
Coronavirus disease 2019 (COVID-19) was declared a global pandemic in March 2020, which precipitated urgent public health responses. The causative agent, SARS-CoV-2, spreads primarily via respiratory droplets, necessitating precautions to mitigate transmission risks. Biopharmaceutical industries and academic institutions worldwide swiftly redirected their research endeavors towards developing therapeutic interventions, focusing on monoclonal antibodies, antiviral agents, and immunomodulatory therapies. The evolving body of evidence surrounding these treatments has prompted successive updates and revisions from the FDA, delineating the evolving landscape of COVID-19 therapeutics. This review comprehensively examines each treatment modality within the context of their developmental trajectories and regulatory approvals throughout the pandemic. Furthermore, it elucidates their mechanisms of action and presents clinical data underpinning their utility in combating the COVID-19 crisis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Drug Discov Today
Year:
2024
Document type:
Article