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Biomimetic nanocomplex based corneal neovascularization theranostics.
Ye, Jinfa; Cheng, Yuhang; Wen, Xiaofei; Han, Yun; Wei, Xingyuan; Wu, Yiming; Chen, Chuan; Su, Min; Cai, Shundong; Pan, Jintao; Liu, Gang; Chu, Chengchao.
Affiliation
  • Ye J; Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, C
  • Cheng Y; Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, C
  • Wen X; Department of Interventional Radiology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361000, China.
  • Han Y; Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, C
  • Wei X; Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, C
  • Wu Y; Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, C
  • Chen C; Department of Pharmacy, Xiamen Medical College, Xiamen 361023, China. Electronic address: cc@xmmc.edu.cn.
  • Su M; Department of Pharmacy, Xiamen Medical College, Xiamen 361023, China.
  • Cai S; Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, C
  • Pan J; Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, C
  • Liu G; State Key Laboratory of Physical Chemistry of Solid Surfaces & The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361002, China; Shen Zhen Research Institute of Xiamen University, Shenzhen 518057, Chi
  • Chu C; Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, C
J Control Release ; 374: 50-60, 2024 Oct.
Article in En | MEDLINE | ID: mdl-39111599
ABSTRACT
Corneal neovascularization (CNV) is a major cause of blindness worldwide. However, the recent drug treatment is limited by repeated administration and low drug bioavailability. In this work, SU6668 (an inhibitor of receptor tyrosine kinases) and indocyanine green (ICG) are loaded onto poly(lactic-co-glycolic acid) (PLGA) nanoparticles, and then coated with anti-VEGFR2 single chain antibody (AbVr2 scFv) genetically engineered cell membrane vesicles. The nanomedicine is delivered via eye drops, and the hyperthermia induced by laser irradiation could block the blood vessels. Meanwhile, the photothermal effect can also cause the degradation of nanomaterials and release chemotherapeutic drugs in the blocked area, thereby continuously inhibit the neovascularization. Furthermore, SU6668 could inhibit the expression of heat shock protein 70 (HSP70), promoting the cell death induced by photothermal effect. In conclusion, the combination of photothermal and chemotherapy drugs provides a novel, effective and safe approach for the treatment of CNV.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Corneal Neovascularization / Nanoparticles / Theranostic Nanomedicine / Polylactic Acid-Polyglycolic Acid Copolymer / Indocyanine Green Limits: Animals / Humans Language: En Journal: J Control Release Year: 2024 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Corneal Neovascularization / Nanoparticles / Theranostic Nanomedicine / Polylactic Acid-Polyglycolic Acid Copolymer / Indocyanine Green Limits: Animals / Humans Language: En Journal: J Control Release Year: 2024 Document type: Article