Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia.
Eur J Neurol
; : e16436, 2024 Aug 12.
Article
in En
| MEDLINE
| ID: mdl-39132977
ABSTRACT
BACKGROUND AND PURPOSE:
This study evaluated associations of brain amyloid with 2-year objective and subjective cognitive measures in a trial-ready older general population at risk for dementia.METHODS:
Forty-eight participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability underwent 11C-Pittsburgh compound B (PiB) positron emission tomography (PET) scans and assessment of cognition (modified Neuropsychological Test Battery [NTB]) and subjective memory complaints (Prospective and Retrospective Memory Questionnaire).RESULTS:
Mean age was 71.4 ± 5.06 years, and 20 participants (42%) had positive baseline PiB-PET scans. Amyloid positivity was associated with lower NTB executive function at baseline and less favorable 2-year NTB total score and memory trajectories, but not with other objective or subjective cognitive measures. Overall, there was little cognitive decline during 2 years.CONCLUSIONS:
Amyloid accumulation may affect objective but not necessarily subjective cognition from a very early at-risk stage, although substantial decline likely requires >2 years to occur.
Full text:
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Eur J Neurol
Year:
2024
Document type:
Article