The Nodes of Ranvier: Mechanisms of Assembly and Maintenance.
Cold Spring Harb Perspect Biol
; 2024 Aug 12.
Article
in En
| MEDLINE
| ID: mdl-39134382
ABSTRACT
Action potential propagation along myelinated axons requires clustered voltage-gated sodium and potassium channels. These channels must be restricted to nodes of Ranvier where the action potential is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon-intrinsic and glial-extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral (PNS) and central (CNS) nervous systems.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Cold Spring Harb Perspect Biol
Year:
2024
Document type:
Article