Your browser doesn't support javascript.
loading
Impact of preexisting interstitial lung disease on outcomes of lung cancer surgery: A monocentric retrospective study.
Goga, Alice; Fourdrain, Alex; Habert, Paul; Nguyen Ngoc, Anh Thu; Bermudez, Julien; Mogenet, Alice; Simon, Eléonore; Gouton, Etienne; Tomasini, Pascale; Thomas, Pascal Alexandre; Greillier, Laurent; Pluvy, Johan.
Affiliation
  • Goga A; Service d'oncologie multidisciplinaires et innovations thérapeutiques, Département de Pneumologie, Hôpital Nord, AP-HM, Marseille, France; Aix Marseille Université, Marseille, France.
  • Fourdrain A; Service de chirurgie thoracique, transplantations pulmonaires et maladies de l'œsophage, Hôpital Nord, AP-HM, Marseille, France; Aix Marseille Université, Marseille, France.
  • Habert P; Service de Radiologie Hôpital Nord, AP-HM, Marseille, France; LIIE/UR 4264, Aix Marseille Université, Marseille, France; Aix Marseille Université, Marseille, France.
  • Nguyen Ngoc AT; CEReSS/UR 3279 Centre d'étude et de recherche sur les services de santé et la qualité de vie, Aix Marseille Université Marseille France, France; Service de Support méthodologique pour les recherche clinique et épidémiologique, AP-HM, Marseille France.
  • Bermudez J; Service des maladies respiratoires rares, mucoviscidose, transplantation, Département de Pneumologie, Hôpital Nord, AP-HM, Marseille, France; Aix Marseille Université, Marseille, France.
  • Mogenet A; Service d'oncologie multidisciplinaires et innovations thérapeutiques, Département de Pneumologie, Hôpital Nord, AP-HM, Marseille, France; Aix Marseille Université, Marseille, France.
  • Simon E; Service d'oncologie multidisciplinaires et innovations thérapeutiques, Département de Pneumologie, Hôpital Nord, AP-HM, Marseille, France; Aix Marseille Université, Marseille, France.
  • Gouton E; Service d'oncologie multidisciplinaires et innovations thérapeutiques, Département de Pneumologie, Hôpital Nord, AP-HM, Marseille, France; Aix Marseille Université, Marseille, France.
  • Tomasini P; Service d'oncologie multidisciplinaires et innovations thérapeutiques, Département de Pneumologie, Hôpital Nord, AP-HM, Marseille, France; Aix Marseille Université, Marseille, France; Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France; INSERM, France; CNRS, France.
  • Thomas PA; Service de chirurgie thoracique, transplantations pulmonaires et maladies de l'œsophage, Hôpital Nord, AP-HM, Marseille, France; Aix Marseille Université, Marseille, France.
  • Greillier L; Service d'oncologie multidisciplinaires et innovations thérapeutiques, Département de Pneumologie, Hôpital Nord, AP-HM, Marseille, France; Aix Marseille Université, Marseille, France; Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France; INSERM, France; CNRS, France.
  • Pluvy J; Service d'oncologie multidisciplinaires et innovations thérapeutiques, Département de Pneumologie, Hôpital Nord, AP-HM, Marseille, France. Electronic address: johan.pluvy@ap-hm.fr.
Respir Med Res ; 86: 101126, 2024 Jul 30.
Article in En | MEDLINE | ID: mdl-39182360
ABSTRACT

INTRODUCTION:

Interstitial lung disease (ILD) is a known risk factor for lung cancer (LC). However, the surgical risk of LC in patients with ILD remains unclear. Therefore, we conducted a single-center retrospective study to assess clinical features and outcomes of LC population who underwent surgery with or without ILD.

METHODS:

Patients who underwent surgery for LC between January 2006 and June 2023 in our center were assessed using data extracted from the nationwide EPITHOR thoracic surgery database. Suspicion of ILD was based on patients' records. Confirmation of ILD was then made on the patient's medical and radiological history. Patients were classified according to the pattern of ILD. The study aimed to describe the outcomes after lung cancer resection in patients with confirmed LC-ILD group compared to those without ILD (LC-non-ILD) post-operative complications, disease-free survival (DFS) and overall survival (OS). A subgroup analysis was also performed on patients with idiopathic pulmonary fibrosis and lung cancer (LC-IPF).

RESULTS:

4073 patients underwent surgery for LC at Assistance Publique des Hôpitaux de Marseille between January 2006 and June 2023. Of these, 4030 were in the LC-non-ILD group and 30 were LC-ILD patients. In the LC-ILD group, the predominant CT scan pattern was probable UIP (50 %). OS was not significantly lower in the LC-ILD group (45 months versus 84 months, p = 0.068). Dyspnea and tumor size were identified as potential univariate predictors of OS. No significant differences were observed on post-operative complications or their severity. The most common post-operative complications in the LC-ILD group were prolonged air leak, respiratory failure, or pneumonia. 13 patients had cancer recurrence in the LC-ILD group.

CONCLUSION:

Our study provides a comprehensive analysis of a LC-ILD population features and outcome when undergoing surgery for LC. Patients with LC-ILD appeared to have a reduced OS compared with LC-non-ILD. Further investigations with larger prospective studies could be useful to confirm and develop these preliminary findings.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Respir Med Res Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Respir Med Res Year: 2024 Document type: Article