Advancements in Combating Fungal Infections: A Comprehensive Review on the Development of Azole Hybrid Antifungals.
Curr Top Med Chem
; 2024 Aug 27.
Article
in En
| MEDLINE
| ID: mdl-39253915
ABSTRACT
OBJECTIVE:
In this review, we have summarized antifungal agents containing potent azole analogues. DATA ACQUISITION The provided literature is related to the development and application of azole derivatives and has been accessed from electronic data bases such as Science direct, Google Scholar, and Pubmed using keywords such as "design, synthesis and evaluation", "azole hybrids", "diazole hybrids", "indazole derivatives", "imidazole derivatives", "triazole derivatives", "tetrazole derivatives" and related combinations.RESULT:
From this review, it was identified that azole derivatives with promising antifungal activity play a vital role in drug discovery and development. The literature revealed that azole derivatives can effectively fight several types of microorganisms, such as Candida albicans, Aspergillus niger, and others. The rational design and structureâactivity relationship of these compounds are discussed in this paper, highlighting their potential as effective therapeutic options against various fungal pathogens. Moreover, this work addresses the challenges and future directions in the development of azole hybrids. The results of docking studies of several of the hybrids that the researchers provided are also summarized.CONCLUSION:
The current work attempts to review such innovations, which may lead to the preparation of novel therapeutics. More research is required to confirm their safety and effectiveness in clinical practices.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Curr Top Med Chem
Year:
2024
Document type:
Article