Mesenchymal stem cells improve depressive disorder via inhibiting the inflammatory polarization of microglia.
J Psychiatr Res
; 179: 105-116, 2024 Sep 08.
Article
in En
| MEDLINE
| ID: mdl-39270422
ABSTRACT
Depressive disorder (DD) ranks among the most prevalent, burdensome, and costly psychiatric conditions globally. It manifests through a range of emotional, cognitive, somatic, and behavioral symptoms. Mesenchymal Stem Cells (MSCs) have garnered significant attention due to their therapeutic potential via immunomodulation in neurological disorders. Our research indicates that MSCs treatment demonstrates a notable effect on a Chronic Unpredictable Mild Stress (CUMS)-induced DD model in mice, surpassing even Fluoxetine in its antidepressant efficacy. MSCs mitigate DD by inhibiting central nervous system inflammation and facilitating the conversion of microglial cells into an Arg1high anti-inflammatory state. The MSCs-derived TGF-ß1 is crucial for this Arg1high microglial cell transformation in DD treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Psychiatr Res
/
J. psychiatr. res
/
Journal of psychiatric research
Year:
2024
Document type:
Article