Effect of hyperbilirubinemia on the pharmacokinetics of diazepam in the rat.
Res Commun Chem Pathol Pharmacol
; 28(1): 133-44, 1980 Apr.
Article
in En
| MEDLINE
| ID: mdl-6893084
ABSTRACT
The pharmacokinetics of intravenously-administered diazepam have been studied in heterozygous (non-jaundiced) and homozygous (jaundiced) Gunn rats following single doses of 10 mg/Kg. Plasma concentration time course data from heterozygous and homozygous animals can be described adequately by biexponential equations. A faster plasma clearance rate (Clp) and shorter elimination half life (t 1/2) as well as reduced volumes of distribution [Vp and Vd(area)] were observed in homozygous animals. These potential effects of bilirubin on the distribution and elimination of diazepam should be considered if diazepam is to be used in the therapy of neonatal hyperbilirubinemia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diazepam
/
Hyperbilirubinemia
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
Res Commun Chem Pathol Pharmacol
Year:
1980
Document type:
Article