Ibuprofen and diflunisal in rheumatoid arthritis: a double-blind comparative trial.

Palmer, D G; Ferry, D G; Gibbins, B L; Hall, S M; Grennan, D M; Lum, J; Myers, D B

Palmer, D G; Ferry, D G; Gibbins, B L; Hall, S M; Grennan, D M; Lum, J; Myers, D B.

N Z Med J ; 94(688): 45-7, 1981 Jul 22.

Article in En | MEDLINE | ID: mdl-7024866

ABSTRACT

Both diflunisal (750 mg/day) and ibuprofen (1600 mg/day) were shown to be superior to placebo in the treatment of rheumatoid arthritis in a double-blind cross-over trial. Neither drug affected lymphocyte transformation to plant mitogens. Diflunisal scored better than ibuprofen at the dose levels chosen but the differences did not reach significance.

Subject(s)

Arthritis, Rheumatoid/drug therapy; Diflunisal/therapeutic use; Ibuprofen/therapeutic use; Salicylates/therapeutic use; Arthritis, Rheumatoid/physiopathology; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lymphocytes/drug effects; Male; Random Allocation

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Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Salicylates / Diflunisal / Ibuprofen Type of study: Clinical_trials Limits: Female / Humans / Male Language: En Journal: N Z Med J Year: 1981 Document type: Article

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