[Rational concepts and the study of active molecules against various trypanosomiases]. / Conception rationnelle et étude de molécules actives contre les différentes trypanosomiases.

ABSTRACT

Several sets of compounds, active against different trypanosomes, Trypanosoma brucei and Trypanosoma cruzi are presented, the lethal doses for some of them being less than the micro-molar concentration. These compounds are designed by taking advantage of two metabolic features of these parasites, glucose metabolism and oxidative stress.