Therapy of human B-cell lymphoma bearing SCID mice is more effective with anti-CD19- and anti-CD38-saporin immunotoxins used in combination than with either immunotoxin used alone.

Flavell, D J; Boehm, D A; Emery, L; Noss, A; Ramsay, A; Flavell, S U

Flavell, D J; Boehm, D A; Emery, L; Noss, A; Ramsay, A; Flavell, S U.

Affiliation

Flavell DJ; Simon Flavell Leukaemia Research Laboratory, Southampton General Hospital, UK.

Int J Cancer ; 62(3): 337-44, 1995 Jul 28.

Article in En | MEDLINE | ID: mdl-7543082

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Burkitt Lymphoma/drug therapy; Immunotoxins/pharmacology; Plant Proteins/pharmacology; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antibodies/pharmacology; Antigens, CD/immunology; Antigens, CD19; Antigens, Differentiation/immunology; Antigens, Differentiation, B-Lymphocyte/immunology; Burkitt Lymphoma/metabolism; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunotoxins/administration & dosage; Male; Membrane Glycoproteins; Mice; Mice, SCID; N-Glycosyl Hydrolases/immunology; Neoplasm Proteins/biosynthesis; Neoplasm Transplantation; Ribosome Inactivating Proteins, Type 1; Saporins; Sodium Dodecyl Sulfate; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Plant Proteins / Antineoplastic Combined Chemotherapy Protocols / Immunotoxins / Burkitt Lymphoma / Antineoplastic Agents, Phytogenic Limits: Animals / Female / Humans / Male Language: En Journal: Int J Cancer Year: 1995 Document type: Article

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