Tyrosines outside the kinase core and dimerization are required for the mitogenic activity of RET/ptc2.

Durick, K; Yao, V J; Borrello, M G; Bongarzone, I; Pierotti, M A; Taylor, S S

Durick, K; Yao, V J; Borrello, M G; Bongarzone, I; Pierotti, M A; Taylor, S S.

Affiliation

Durick K; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093-0654, USA.

J Biol Chem ; 270(42): 24642-5, 1995 Oct 20.

Article in En | MEDLINE | ID: mdl-7559572

Subject(s)

Cyclic AMP-Dependent Protein Kinases/physiology; Drosophila Proteins; Mitogens/chemistry; Proto-Oncogene Proteins/chemistry; Receptor Protein-Tyrosine Kinases/chemistry; Tyrosine/metabolism; Animals; Cells, Cultured; Mice; Mitogens/pharmacology; Mutagenesis, Site-Directed; Phosphorylation; Proto-Oncogene Proteins/pharmacology; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases/pharmacology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Tyrosine / Proto-Oncogene Proteins / Receptor Protein-Tyrosine Kinases / Cyclic AMP-Dependent Protein Kinases / Drosophila Proteins / Mitogens Limits: Animals Language: En Journal: J Biol Chem Year: 1995 Document type: Article

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