Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors.

Joao, H C; De Vreese, K; Pauwels, R; De Clercq, E; Henson, G W; Bridger, G J

Joao, H C; De Vreese, K; Pauwels, R; De Clercq, E; Henson, G W; Bridger, G J.

Affiliation

Joao HC; Sandoz Research Institute, Vienna, Austria.

J Med Chem ; 38(19): 3865-73, 1995 Sep 15.

Article in En | MEDLINE | ID: mdl-7562918

Subject(s)

Antiviral Agents/chemistry; Antiviral Agents/pharmacology; HIV-1/drug effects; HIV-2/drug effects; Heterocyclic Compounds/chemistry; Heterocyclic Compounds/pharmacology; Antiviral Agents/chemical synthesis; Benzylamines; Computer Simulation; Cyclams; Drug Design; Giant Cells; HIV Envelope Protein gp120/metabolism; HIV-1/physiology; HIV-2/physiology; Heterocyclic Compounds/chemical synthesis; Humans; Least-Squares Analysis; Models, Chemical; Molecular Conformation; Molecular Structure; Software; Structure-Activity Relationship; Virus Replication/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / HIV-1 / HIV-2 / Heterocyclic Compounds Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Year: 1995 Document type: Article

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