Rhabdoid tumours of the central nervous system. Report of three cases with immunocytochemical and ultrastructural findings.
Virchows Arch A Pathol Anat Histopathol
; 422(1): 81-5, 1993.
Article
in En
| MEDLINE
| ID: mdl-7679853
ABSTRACT
Three cases of rhabdoid tumour of the central nervous system arising in a supratentorial location are reported. The patients were 18, 14, and 7 years old. All three tumours showed a common morphology. The neoplastic cells were usually globoid with round nuclei and prominent nucleoli and large acidophilic, cytoplasmic inclusions were present in many of them. These inclusions showed strong immunoreactivity for vimentin, weak immunoreactivity for epithelial membrane antigen and focal immunoreactivity for cytokeratins. Ultrastructurally they were made up of whorls of intermediate filaments, 8-10 nm in thickness. Rhabdoid tumours of the central nervous system, whatever the cell of origin, appear to be an independent entity with identifiable histology and aggressive behaviour.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cerebellar Neoplasms
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Virchows Arch A Pathol Anat Histopathol
Year:
1993
Document type:
Article