The tetratricopeptide repeat-domain of the PAS10 protein of Saccharomyces cerevisiae is essential for binding the peroxisomal targeting signal-SKL.
Biochem Biophys Res Commun
; 204(3): 1016-22, 1994 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-7980572
ABSTRACT
The PAS10 gene was found in a two-hybrid screen for the isolation of genes encoding proteins which interact with the C-terminal peroxisomal targeting signal -SKL. The PAS10 protein is known to be involved in import of proteins into peroxisomes and to contain a tetratricopeptide repeat (TPR) domain. All TPR-containing proteins involved in diverse processes like mitosis or RNA-synthesis share the ability to interact with other proteins. Here we show that the PAS10 protein interacts in vivo with the C-terminal peroxisomal targeting signal. The part essential for this interaction contains the complete tetratricopeptide repeat domain.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Membrane Transport Proteins
/
Saccharomyces cerevisiae
/
Fungal Proteins
/
Carrier Proteins
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
1994
Document type:
Article