Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons.

Sonnewald, U; Westergaard, N; Schousboe, A; Svendsen, J S; Unsgård, G; Petersen, S B

Sonnewald, U; Westergaard, N; Schousboe, A; Svendsen, J S; Unsgård, G; Petersen, S B.

Affiliation

Sonnewald U; MR-Center, SINTEF UNIMED, Trondheim, Norway.

Neurochem Int ; 22(1): 19-29, 1993 Jan.

Article in En | MEDLINE | ID: mdl-8095170

Subject(s)

Astrocytes/metabolism; Glutamine/metabolism; Magnetic Resonance Spectroscopy; Neurons/metabolism; gamma-Aminobutyric Acid/biosynthesis; Acetates/metabolism; Animals; Cells, Cultured; Cerebral Cortex/cytology; Cerebral Cortex/metabolism; Gas Chromatography-Mass Spectrometry; Glucose/metabolism; Glutamate-Ammonia Ligase/antagonists & inhibitors; Glutamates/metabolism; Glutamic Acid; Methionine Sulfoximine/pharmacology; Mice

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Collection: 01-internacional Database: MEDLINE Main subject: Magnetic Resonance Spectroscopy / Astrocytes / Gamma-Aminobutyric Acid / Glutamine / Neurons Limits: Animals Language: En Journal: Neurochem Int Year: 1993 Document type: Article

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