Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2.

Beaton, H G; Bennion, C; Connolly, S; Cook, A R; Gensmantel, N P; Hallam, C; Hardy, K; Hitchin, B; Jackson, C G; Robinson, D H

Beaton, H G; Bennion, C; Connolly, S; Cook, A R; Gensmantel, N P; Hallam, C; Hardy, K; Hitchin, B; Jackson, C G; Robinson, D H.

Affiliation

Beaton HG; Department of Medicinal Chemistry, Fisons plc, Loughborough, Leicestershire, U.K.

J Med Chem ; 37(5): 557-9, 1994 Mar 04.

Article in En | MEDLINE | ID: mdl-8126692

Subject(s)

Benzhydryl Compounds/chemistry; Phospholipases A/antagonists & inhibitors; gamma-Aminobutyric Acid/analogs & derivatives; Animals; Benzhydryl Compounds/pharmacology; Binding Sites; Blood Platelets/enzymology; Drug Design; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pancreas/enzymology; Phospholipases A/metabolism; Structure-Activity Relationship; Swine; gamma-Aminobutyric Acid/chemistry; gamma-Aminobutyric Acid/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Phospholipases A / Benzhydryl Compounds / Gamma-Aminobutyric Acid Limits: Animals / Humans Language: En Journal: J Med Chem Year: 1994 Document type: Article

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