[The influence of n-acetylcysteine on chemiluminescence of granulocytes in peripheral blood of patients with chronic bronchitis]. / Wplyw N-acetylcysteiny na chemiluminescencje granulocytów krwi obwodowej u chorych na przewlekle zapalenie oskrzeli.
Pneumonol Alergol Pol
; 61(11-12): 586-91, 1993.
Article
in Pl
| MEDLINE
| ID: mdl-8148757
ABSTRACT
The effect of NAC on exacerbation of chronic obstructive pulmonary disease (COPD) may be due to its mucolytic properties due to the thiol group of NAC and to its reducing and antioxidant properties. It has been postulated that NAC may protect lung cells from inhaled oxidants or oxidants produced by inflammatory leukocytes by increasing intra and extra cellular GSH. The FMLP induced granulocyte chemiluminescence (CL) in 6 healthy and 12 patients with COPD was determined. Peripheral blood polymorphonuclear leukocytes were incubated with NAC. The results obtained show a significant decrease of CL after incubation with NAC in both groups. We also found higher CL in healthy subjects than patients with COPD. This study showed a significant increase of FVC, FEV1 and a significant decrease of granulocyte CL after treatment with oral NAC 200 mg three times daily for 3 weeks.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acetylcysteine
/
Granulocytes
/
Lung Diseases, Obstructive
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Pl
Journal:
Pneumonol Alergol Pol
Year:
1993
Document type:
Article