Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties.

Monge, A; Peña, M C; Palop, J A; Calderó, J M; Roca, J; García, E; Romero, G; del Río, J; Lasheras, B

Monge, A; Peña, M C; Palop, J A; Calderó, J M; Roca, J; García, E; Romero, G; del Río, J; Lasheras, B.

Affiliation

Monge A; Dpto. Química Orgánica, CIFA Universidad de Navarra, Pamplona, Spain.

J Med Chem ; 37(9): 1320-5, 1994 Apr 29.

Article in En | MEDLINE | ID: mdl-8176710

Subject(s)

Piperazines/chemical synthesis; Serotonin Antagonists/chemical synthesis; Serotonin Receptor Agonists/chemical synthesis; Thiazoles/chemical synthesis; Animals; Benzothiazoles; Binding, Competitive; Cerebral Cortex/metabolism; Female; Gastric Emptying/drug effects; Granisetron/metabolism; Guinea Pigs; Ileum/drug effects; Ileum/physiology; Male; Molecular Structure; Mucous Membrane/drug effects; Mucous Membrane/physiology; Ondansetron/pharmacology; Piperazines/pharmacology; Rats; Rats, Sprague-Dawley; Rats, Wistar; Serotonin/pharmacology; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/pharmacology; Thiazoles/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Serotonin Antagonists / Thiazoles / Serotonin Receptor Agonists Limits: Animals Language: En Journal: J Med Chem Year: 1994 Document type: Article

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