Therapy-related myelodysplastic syndrome. Two cytogenetically unrelated abnormal clones in a patient with multiple myeloma.
Cancer Genet Cytogenet
; 70(2): 117-9, 1993 Oct 15.
Article
in En
| MEDLINE
| ID: mdl-8242590
ABSTRACT
A multiple myeloma patient presented for cytogenetic analysis at diagnosis of secondary MDS, which followed cytotoxic treatment including melphalan. Two abnormal unrelated clones were detected, one of them had 5q-, 7q- with clonal evolution of an additional aberration, t(12;13); in the second clone there was a translocation between the two homologues of chromosome 1 as the only aberration. We suggest that the clone with 5q- and 7q- represented the secondary MDS cells, whereas the abnormal clone with t(1;1) represented the plasmablasts of the multiple myeloma.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Myelodysplastic Syndromes
/
Chromosomes, Human, Pair 1
/
Chromosomes, Human, Pair 5
/
Chromosomes, Human, Pair 7
/
Multiple Myeloma
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Cancer Genet Cytogenet
Year:
1993
Document type:
Article