Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT).

Springer, C J; Dowell, R; Burke, P J; Hadley, E; Davis, D H; Blakey, D C; Melton, R G; Niculescu-Duvaz, I

Springer, C J; Dowell, R; Burke, P J; Hadley, E; Davis, D H; Blakey, D C; Melton, R G; Niculescu-Duvaz, I.

Affiliation

Springer CJ; Cancer Research Campaign Centre for Cancer Therapeutic, Institute of Cancer Research, Sutton, Surrey, U.K.

J Med Chem ; 38(26): 5051-65, 1995 Dec 22.

Article in En | MEDLINE | ID: mdl-8544182

Subject(s)

Antineoplastic Agents, Alkylating/chemical synthesis; Nitrogen Mustard Compounds/chemical synthesis; Prodrugs/chemical synthesis; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating/chemistry; Antineoplastic Agents, Alkylating/pharmacology; Cell Survival/drug effects; Humans; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Nitrogen Mustard Compounds/chemistry; Nitrogen Mustard Compounds/pharmacology; Prodrugs/chemistry; Prodrugs/pharmacology; Tumor Cells, Cultured; gamma-Glutamyl Hydrolase

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Antineoplastic Agents, Alkylating / Nitrogen Mustard Compounds Limits: Humans Language: En Journal: J Med Chem Year: 1995 Document type: Article

Search on Google

XML

PubMed Links