Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.

Chen, H; Charlat, O; Tartaglia, L A; Woolf, E A; Weng, X; Ellis, S J; Lakey, N D; Culpepper, J; Moore, K J; Breitbart, R E; Duyk, G M; Tepper, R I; Morgenstern, J P

Chen, H; Charlat, O; Tartaglia, L A; Woolf, E A; Weng, X; Ellis, S J; Lakey, N D; Culpepper, J; Moore, K J; Breitbart, R E; Duyk, G M; Tepper, R I; Morgenstern, J P.

Affiliation

Chen H; Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA.

Cell ; 84(3): 491-5, 1996 Feb 09.

Article in En | MEDLINE | ID: mdl-8608603

Subject(s)

Carrier Proteins/genetics; Diabetes Mellitus, Type 1/genetics; Diabetes Mellitus, Type 1/metabolism; Point Mutation; Proteins/metabolism; Receptors, Cell Surface; Receptors, Cytokine/genetics; Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; DNA Primers/genetics; DNA, Complementary/genetics; Humans; Leptin; Mice; Mice, Inbred Strains; Mice, Obese; Molecular Sequence Data; Obesity/genetics; Obesity/metabolism; Phenotype; Polymerase Chain Reaction; Receptors, Leptin; Sequence Homology, Amino Acid; Signal Transduction

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Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Carrier Proteins / Point Mutation / Receptors, Cytokine / Receptors, Cell Surface / Diabetes Mellitus, Type 1 Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Cell Year: 1996 Document type: Article

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