The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma.

Borrello, M G; Alberti, L; Arighi, E; Bongarzone, I; Battistini, C; Bardelli, A; Pasini, B; Piutti, C; Rizzetti, M G; Mondellini, P; Radice, M T; Pierotti, M A

Borrello, M G; Alberti, L; Arighi, E; Bongarzone, I; Battistini, C; Bardelli, A; Pasini, B; Piutti, C; Rizzetti, M G; Mondellini, P; Radice, M T; Pierotti, M A.

Affiliation

Borrello MG; Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, Italy.

Mol Cell Biol ; 16(5): 2151-63, 1996 May.

Article in En | MEDLINE | ID: mdl-8628282

Subject(s)

Drosophila Proteins; Isoenzymes/metabolism; Oncogene Proteins/genetics; Oncogene Proteins/metabolism; Protein-Tyrosine Kinases/biosynthesis; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases/genetics; Receptor Protein-Tyrosine Kinases/metabolism; Recombinant Fusion Proteins/biosynthesis; Type C Phospholipases/metabolism; Tyrosine; 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Glutathione Transferase/biosynthesis; HeLa Cells; Humans; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oncogene Proteins/biosynthesis; Phenylalanine; Phosphopeptides/chemistry; Phosphorylation; Proto-Oncogene Proteins/biosynthesis; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases/biosynthesis; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Type C Phospholipases / Tyrosine / Recombinant Fusion Proteins / Protein-Tyrosine Kinases / Proto-Oncogenes / Proto-Oncogene Proteins / Oncogene Proteins / Receptor Protein-Tyrosine Kinases / Drosophila Proteins / Isoenzymes Limits: Animals / Humans Language: En Journal: Mol Cell Biol Year: 1996 Document type: Article

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