New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link.

Dowell, R I; Springer, C J; Davies, D H; Hadley, E M; Burke, P J; Boyle, F T; Melton, R G; Connors, T A; Blakey, D C; Mauger, A B

Dowell, R I; Springer, C J; Davies, D H; Hadley, E M; Burke, P J; Boyle, F T; Melton, R G; Connors, T A; Blakey, D C; Mauger, A B.

Affiliation

Dowell RI; Cancer Research Department, Zeneca Pharmaceutical, Cheshire, U.K.

J Med Chem ; 39(5): 1100-5, 1996 Mar 01.

Article in En | MEDLINE | ID: mdl-8676345

Subject(s)

Aniline Mustard/analogs & derivatives; Antineoplastic Agents/chemical synthesis; Immunotoxins; Prodrugs/chemical synthesis; gamma-Glutamyl Hydrolase/metabolism; Aniline Mustard/chemical synthesis; Aniline Mustard/metabolism; Aniline Mustard/pharmacology; Cell Death; Cell Division/drug effects; Colorectal Neoplasms/pathology; Humans; Molecular Structure; Tumor Cells, Cultured

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Gamma-Glutamyl Hydrolase / Immunotoxins / Aniline Mustard / Antineoplastic Agents Limits: Humans Language: En Journal: J Med Chem Year: 1996 Document type: Article

Search on Google

XML

PubMed Links