Effects of feeding on protein turnover in healthy children and in children with cystic fibrosis.
Am J Clin Nutr
; 64(4): 608-14, 1996 Oct.
Article
in En
| MEDLINE
| ID: mdl-8839507
ABSTRACT
We hypothesized that there is less suppression of whole-body protein breakdown with feeding in patients with cystic fibrosis (CF) who exhibit decreased insulin secretion after a single meal. Using [1-13C]leucine, we measured rates of nonoxidative leucine disappearance (whole-body protein synthesis) and protein breakdown in nine CF patients (6-11 y of age) and five healthy control subjects (8-10 y of age) during feeding and fasting. In the CF patients, synthesis and breakdown (x +/- SD) were 172 +/- 61 and 157 +/- 67 mumol.kg-1.h-1 during feeding and 140 +/- 24 and 178 +/- 26 mumol.kg-1.h-1 during fasting. The respective control values were 129 +/- 27 and 114 +/- 20 mumol.kg-1.h-1 during feeding and 136 +/- 13 and 173 +/- 18 mumol.kg-1.h-1 during fasting. Leucine balance was nearly identical in the two groups. By analysis of variance, there was a significant effect of feeding on protein breakdown but no difference between the groups. However, when each group was analyzed separately, feeding resulted in a 34% decrease in breakdown in the control subjects (P = 0.001) and a 23% increase in synthesis in the CF group (P = 0.058). Plasma insulin concentrations did not differ in the two groups. Thus, feeding may affect protein turnover differently in children with CF than in control children independently of plasma insulin concentration.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dietary Proteins
/
Cystic Fibrosis
/
Eating
Type of study:
Observational_studies
Limits:
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Am J Clin Nutr
Year:
1996
Document type:
Article