Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton.

Southgate, C D; Chishti, A H; Mitchell, B; Yi, S J; Palek, J

Southgate, C D; Chishti, A H; Mitchell, B; Yi, S J; Palek, J.

Affiliation

Southgate CD; Department of Biomedical Research, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA.

Nat Genet ; 14(2): 227-30, 1996 Oct.

Article in En | MEDLINE | ID: mdl-8841202

Subject(s)

Anemia, Hemolytic/blood; Anion Exchange Protein 1, Erythrocyte/physiology; Gene Targeting; Spherocytes/cytology; Alleles; Anemia, Hemolytic/genetics; Animals; Anion Exchange Protein 1, Erythrocyte/analysis; Anion Exchange Protein 1, Erythrocyte/genetics; Cell Membrane/ultrastructure; Erythrocyte Membrane/chemistry; Erythrocytes/chemistry; Erythrocytes/ultrastructure; Genes/genetics; Growth; Homozygote; Kidney/chemistry; Kidney/cytology; Membrane Proteins/analysis; Mice; Mice, Mutant Strains; Spherocytes/ultrastructure; Splenomegaly

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Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Spherocytes / Anion Exchange Protein 1, Erythrocyte / Gene Targeting / Anemia, Hemolytic Limits: Animals Language: En Journal: Nat Genet Year: 1996 Document type: Article

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