In vitro evaluation of polymeric matrix and porous biodegradable reservoir devices for slow-release drug delivery.
Ophthalmic Surg Lasers
; 27(5): 384-91, 1996 May.
Article
in En
| MEDLINE
| ID: mdl-8860606
ABSTRACT
BACKGROUND AND OBJECTIVE:
Biodegradable polymeric devices were evaluated in vitro for intravitreal drug delivery. MATERIALS ANDMETHODS:
The matrix (short-term drug delivery) and the porous (longer-term drug delivery) reservoir devices were made from polycaprolactone of two molecular weights (30,000 and 56,000). Matrix devices were loaded with 5-fluorouracil or ganciclovir. Porous reservoirs were loaded with 5-fluorouracil, ganciclovir, 5-carboxyfluorescein, or foscarnet. The release was monitored in phosphate-buffered solution using ultraviolet spectrophotometry.RESULTS:
Release from the matrix devices was characterized by an initial burst, followed by a nonlinear release. The porous reservoirs demonstrated zero order linear release of drugs, sustained up to 250 days in this experiment.CONCLUSIONS:
The matrix device is capable of sustained release over several months; the porous reservoir can deliver drugs for over 1 year. Further studies are needed to evaluate in vivo biodegradation behavior and toxicity of drugs used for sustained release.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Polyesters
/
Ganciclovir
/
Drug Delivery Systems
/
Foscarnet
/
Fluoresceins
/
Fluorouracil
Language:
En
Journal:
Ophthalmic Surg Lasers
Year:
1996
Document type:
Article