Transcriptional up-regulation of intracellular adhesion molecule-1 in human endothelial cells by the antioxidant pyrrolidine dithiocarbamate involves the activation of activating protein-1.

Muñoz, C; Castellanos, M C; Alfranca, A; Vara, A; Esteban, M A; Redondo, J M; de Landázuri, M O

Muñoz, C; Castellanos, M C; Alfranca, A; Vara, A; Esteban, M A; Redondo, J M; de Landázuri, M O.

Affiliation

Muñoz C; Immunology Service, La Princesa Hospital, Autonomous University of Madrid, Spain.

J Immunol ; 157(8): 3587-97, 1996 Oct 15.

Article in En | MEDLINE | ID: mdl-8871659

Subject(s)

Antioxidants/pharmacology; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Intercellular Adhesion Molecule-1/genetics; Pyrrolidines/pharmacology; Thiocarbamates/pharmacology; Transcription Factor AP-1/metabolism; Base Sequence; Cells, Cultured; DNA/genetics; DNA/metabolism; Endothelium, Vascular/cytology; Humans; Inflammation Mediators/pharmacology; Oligonucleotide Probes/genetics; Oxidation-Reduction; Promoter Regions, Genetic/drug effects; RNA, Messenger/genetics; RNA, Messenger/metabolism; Transcriptional Activation/drug effects; Transfection; Tumor Necrosis Factor-alpha/pharmacology; Up-Regulation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Thiocarbamates / Endothelium, Vascular / Transcription Factor AP-1 / Intercellular Adhesion Molecule-1 / Antioxidants Limits: Humans Language: En Journal: J Immunol Year: 1996 Document type: Article

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