Thrombocytemia and abnormal megakaryopoiesis associated with abnormality of chromosome 1p34 in myelodysplastic syndromes.
Leukemia
; 10(11): 1692-5, 1996 Nov.
Article
in En
| MEDLINE
| ID: mdl-8892668
ABSTRACT
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by a cytopenia related to abnormal proliferation and differentiation of marrow precursor cells. Some subtypes of MDS are associated with thrombocytemia or abnormal megakaryopoiesis and certain specific karyotypic abnormalities. We report on four cases of MDS with normal or elevated blood platelet count and a recurring abnormality in chromosome 1p34. The gene involved appears to be different from c-mpl and TPO.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombocytopenia
/
Myelodysplastic Syndromes
/
Chromosomes, Human, Pair 1
/
Chromosome Aberrations
/
Chromosome Disorders
/
Hematopoiesis
Type of study:
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Leukemia
Year:
1996
Document type:
Article