[Clinical, pharmacokinetic and therapeutic study of amikacin with single daily dose and in combination in neutropenic children with fever]. / Etude clinique, pharmacocinétique et thérapeutique de l'amikacine en dose unique journalière et en association chez l'enfant neutropénique fébrile.
Arch Pediatr
; 3(9): 854-60, 1996 Sep.
Article
in Fr
| MEDLINE
| ID: mdl-8949344
ABSTRACT
BACKGROUND:
The efficacy of single daily dose of amikacin has been recently demonstrated in neutropenic children with fever. POPULATION ANDMETHODS:
Eighteen children aged 1 to 15 years were included in the study. All patients were febrile and granulocytopenic and had indwelling intravenous catheter. Amikacin was administered as a 30-minute intravenous infusion once daily (20 mg/kg on day 1, then 15 mg/kg) for 3 to 30 days; the patients received amikacin in combination with piperacillin and vancomycin. Serum levels of amikacin were measured on days 1, 3, 6 and 10, and 30 min, 60 min and 180 min after the end of the infusion.RESULTS:
All patients responded favourably to the antibiotic therapy. Sixty-two kinetics were performed peak amikacin concentrations measured (30 min after 30-min infusion) on day 1 averaged 43.7 micrograms/mL (+/- 13.8). A significant increase in peak serum concentrations was observed during the treatment (day 3 vs day 10) without change in the trough serum concentrations. The volumes of distribution were considerably important in these granulocytopenic children and there was a large inter and intra-patient variability; the elimination half-life of the amikacin was short (1.45 h). There was no significant nephrotoxicity in any patient.CONCLUSION:
The use of single daily dose amikacin in combination with a broad spectrum beta-lactam antibiotic and vancomycin was efficient and safe in febrile granulocytopenic children. The simulation of the amikacin behaviour in the deep compartment should be evaluated; in fact, it might reflect better accumulation of the drug than serum concentrations.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amikacin
/
Fever
/
Anti-Bacterial Agents
/
Neutropenia
Type of study:
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
Language:
Fr
Journal:
Arch Pediatr
Year:
1996
Document type:
Article