Introducing a point mutation identified in a patient with pituitary resistance to thyroid hormone (Arg 338 to Trp) into other mutant thyroid hormone receptors weakens their dominant negative activities.

Ando, S; Nakamura, H; Sasaki, S; Nishiyama, K; Kitahara, A; Nagasawa, S; Mikami, T; Natsume, H; Genma, R; Yoshimi, T

Ando, S; Nakamura, H; Sasaki, S; Nishiyama, K; Kitahara, A; Nagasawa, S; Mikami, T; Natsume, H; Genma, R; Yoshimi, T.

Affiliation

Ando S; Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.

J Endocrinol ; 151(2): 293-300, 1996 Nov.

Article in En | MEDLINE | ID: mdl-8958790

Subject(s)

Pituitary Gland/metabolism; Point Mutation; Receptors, Thyroid Hormone/genetics; Thyroid Hormone Resistance Syndrome/genetics; Transcription, Genetic; Cells, Cultured; Dimerization; Humans

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Collection: 01-internacional Database: MEDLINE Main subject: Pituitary Gland / Transcription, Genetic / Receptors, Thyroid Hormone / Point Mutation / Thyroid Hormone Resistance Syndrome Limits: Humans Language: En Journal: J Endocrinol Year: 1996 Document type: Article

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